Simple techniques can save many hours of troubleshooting and downtime. Sample filtration should also be considered when there is a risk of insoluble material entering the system. The problem of blocked frits is highlighted in: ACE Ultra Low Dispersion, High Quality UHPLC and HPLC Pre-column Filters. Using in-line filters and column guards can reduce the incidence of blockages in a chromatography system, so preventing peak problems. If so, change the solvent and whenever possible, inject samples in the mobile phase.
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